Life Science Hotlist

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The Stockholm-Uppsala Life Science Investment Hotlist features a carefully selected list of investment cases from one of the world’s leading knowledge regions. Curated by Invest Stockholm , the list is a tool for investors focused on disruptive commercial innovation in life science. The hotlist is updated continuously so stay tuned. This project is supported by the European Union.

Category
Sub Category
  • Abera Bioscience - has developed next-generation bacterial and derived OMV vaccine delivery platforms that combine high-level multivalent antigen presentation with strong stimulation of the immune system.

    Go to website
  • Affibody - develops next generation biopharmaceuticals based on its unique proprietary technology platforms: Affibody® molecules and Albumod™

    Go to website
  • AlzeCure - develops innovative therapies for the treatment of Alzheimer ́s disease and related neurodegenerative disorders, as well as unique medical technologies for efficient CNS drug delivery and dynamic in vivo detection of biomarkers.

    More About AlzeCure

    Target market

    • Neurodegenerative diseases, e.g. Alzheimer’s Disease (AD), are debilitating CNS conditions for which there is no curative or preventive treatment available.
    • The field is hampered by limited disease understanding, difficulties to set appropriate diagnosis and inconclusive clinical trials.

    Product/Business idea

    • Identify and pursue drug targets that exhibit a clear linkage to well-defined patient populations.
    • Combine technology and biology innovation to deliver efficacious therapies.

    Product development and expansion

    • Approximately 115 million people are estimated to be suffering from AD in 2050, indicating a significant market potential for a novel disease modifying therapy.
    alzecure.org
  • Athera - is a clinical stage biopharmaceutical company focused on developing targeted anti-inflammatory biological candidate drugs and companion diagnostics for the prevention and treatment of cardiovascular disease.

    Go to website
  • BioLamina - Stem cell culturing made easy.

    Go to website
  • Biosync Technology - offers a wearable biofeedback system for stress management and lifestyle tracking in the daily environment. The system offers great potential in various applications e.g. cost savings by primary and secondary prevention of stress related diseases.

    More About Biosync Technology

    Target market

    • Stress is an epidemic of 21st century, causing huge financial losses to economies.
    • It is an unmet need in terms of measuring and identifying causes of stress, as well as making insights actionable for behavioral change to decrease health issues.

    Product/Business idea

    • A wearable sensor biofeedback system for stress management in the daily environment.

    Product development and expansion

    • Global and scalable solution. Eight verticals defined and verified.

    Two focus areas:

    • Occupational Healthcare: $25M USD in 3-5 years in Nordic Market only
    • Pharmaceutical Companies: $15M USD in 3-5 years for one chronic condition only
    biosynctechnology.com
  • Biovica - blood Assays for prognosis and monitoring of cancer

    More About Biovica - Founded in 2009

    Target market

    • How will the cancer disease develop?
    • How do we know if a cancer treatment gives desired effect or not?

    Product/Business idea

    • DiviTum™ can allow for earlier detection
    • DiviTum™ has the ability to prognosticate cancer disease development
    • DiviTum™ can monitor the effect of a cancer treatment

    Product development and expansion

    • >12.6 M people get cancer every year
    • Europe & US alone (~15% world population) USD >5 Billions
    www.biovica.com
  • Blodkollen - provides easy and rapid blood analysis to facilitate the assessment of a person’s training and eating habits.

    More About Blodkollen

    Target market

    • Today the healthcare is only focused on treating ill patient rather than focusing on how to prevent illness.
    • Regular health checks are needed to prevent health problems.
    • Wellbeing up until today has been focused a on how you look or what you eat, with very little focus on how your body responds to your life.

    Product/Business idea

    • Preventive healthcare with blood analysis.
    • Blood samples ordered online and sampled through 100+ third party clinics. 
    • Third party services, such as diet-, fitness- and medical-services to improve health.

    Product development and expansion

    • Further and structured marketing, primarily through PR, events and partnerships.
    • Optimize sales conversion and branding/packaging Identification of and preparation for next two markets.

     

    blodkollen.se
  • Bonzun Health Information - offers pregnant women and expecting fathers high quality medical information and live chat with medical professionals. All in one app that will keep the pregnant woman and child safe. 

    More About Bonzun Health Information

    Target market

    • Many health care facilities lack obstetric doctors and are insufficient for patients.
    • Pregnant women with sensitive questions has no one to turn to and crowded waiting rooms hesitate them to go to the hospital with minor questions.
    • China has the highest amount of suicide among women in the world, WHO link this to lack of support during pregnancy.

    Product/Business idea

    • An all-in-one app that will keep the pregnant woman and child safe.

    Product development and expansion

    • Market scale for E-health in China was ~480 million USD in 2014, a 26.8% increase from previous year. The market scale is expected to be 2 billion USD by 2017
    • 10% of the Chinese population earned more than 120 000 USD a year in 2014. Their main concern is their health and 82% of wealthy Chinese don’t have a family doctor.
    bonzun.com
  • C-sense - is a company offering intelligent sensors for a variety of applications. C-sense has developed C-nose, a multi-sensor electronic nose that can be used as a bomb-nose as well as in food control and medical diagnostics.

    More About C-sense - Founded in 2011

    Target market

    • To deliver cost efficient, fast and reliable quality control and health diagnoses.

    Product/Business idea

    • C-sense has developed an unique electronic nose that senses smell, detects and identifies various substances.

    Product development and expansion

    • C-sense’s electronic nose has been tested on a range of different scents, such as e.g. ovarian cancer with remarkably good results.
    • Initially, C-sense will focus on the crop quality market where the market need is around 15,000 units only in Europe.
    c-sense.se
  • Diamyd Medical - is dedicated to finding a cure for autoimmune diabetes through pharmaceutical development and investments in medtech and stem cell technology.

    More About Diamyd Medical - Founded in 1996

    Target market

    • Type 1 diabetes is a serious disease affecting children
    • Current treatment paradigm is not addressing the root cause of disease

    Product/Business idea

    • Diamyd Medical’s diabetes vaccine Diamyd® is a disease modifying agent
    • Good safety profile and ease of use

    Product development and expansion

    • 80,000 new patients per year
    • Large savings potential for healthcare system
    • No competitor on or close to market
    www.diamyd.com
  • Glucox Biotech - Identifies and develops selective and specific Nox4 inhibitors with drug like properties.

    Go to website
  • Gnosco - has developed, Dermicus, an easy-to-use, flexible and secure decision support system for skin cancer and wounds. The app and platform is specifically aimed for communication between healthcare providers.

    More About Gnosco

    Target market

    • 500 people in Sweden die every year in Melanoma and the cost of skin cancer care in Sweden exceeds 1.6 billion SEK per year
    • Delayed diagnosis of Melanoma directly impacts patient survival

    Product/Business idea

    • Dermicus is an easy-to-use, flexible and secure decision support system for skin cancer and wounds.
    • The platform is specifically aimed for communication between healthcare providers and the effect is a faster and more efficient medical process and improved patient experience.

    Product development and expansion

    • The European mHealth market will be worth $7.1 billion by 2018 with an annual growth of 61.6% per year.
    gnosco.com
  • Gradientech - Gradientech develops a rapid diagnostic platform that generates phenotypic antibiotic susceptibility testing (AST) results in just 2 hours.

    Go to website
  • iCellate - detects cancer before there are symptoms. It is achieved by capturing the single cells that spread the disease, the Circulating Tumor Cells (CTC).

    More About iCellate

    Target market

    Product/Business idea

    Product development and expansion

    icellate.se
  • Immuneed - is an immuno-oncology company focusing on therapeutic vaccine development with a new targeting platform. Immuneed also offers a specialized service for advanced characterization of biopharmaceuticals in an ex vivo system, which can predict clinical outcome, thereby reducing the need for animal studies, and indicate clinical effects at an earlier stage.

    More About Immuneed

    Target market

    Product/Business idea

    Product development and expansion

    Immuneed.com
  • InDex Pharmaceuticals - develops Kappaproct, which is in late stage clinical development for ulcerative colitis with a novel mechanism of action that has shown clinical proof of concept and is safe and well tolerated.

    More About InDex Pharmaceuticals

    Target market

    • Ulcerative colitis (UC) is a chronic inflammation of the colon with high unmet medical need in moderate to severe UC
    • Current treatments with biologics are limited du to efficacy and safety problems

    Product/Business idea

    • Kappaproct provides local anti-inflammatory effects and resolves the clinical symptoms with a novel mechanism of action that is safe and well tolerated

    Product development and expansion

    • $4 Bn/year in biologics sales in UC
    • Kappaproct has blockbuster potential in UC as a safer and more efficacious alternative to biologics
    www.indexpharma.com
  • IsletOne Therapeutics - proprietary clinical-stage off-the-shelf cell therapeutics within inflammation and autoimmunity, combined with an extensive pipeline of promising pre-clinical projects.

    Go to website
  • Mando Group - A consumer version of an evidence based bio feedback device, used successfully to treat eating disorders for twenty years, has proven effective in weight loss.

    More About Mando Group - Founded in 2000

    Target market

    • Globally 1.5 billion are overweight/obese.
    • Unsolved, huge medical/economic problem.
    • There is no effective non-invasive treatment  available.

    Product/Business idea

    • A consumer version of an evidence based bio feedback device, used successfully to treat eating disorders for twenty years, has proven effective in weight loss.

    Product development and expansion

    • Global weight loss market is estimated to be €800 billion by 2015.
    www.mando.se
  • Med Universe - patient case software offered to the life science industry to effectively inform, educate and engage health care professionals about new treatments, therapies and devices via digital patient cases.

    More About Med Universe

    Target market

    • The life science industry is struggling to find effective solutions to engage health care practitioners (HCP) with educational information and marketing messages.
    • The currently applied methods neither involve HCPs nor collect data from interactions in a systematic way.

    Product/Business idea

    • The software makes it possible for clients to truly engage HCPs around relevant patient case content.
    • The benefits are cost effective information and education as well as multi channel marketing and distribution (Business intelligence).

    Product development and expansion

    • Western Europe (15 countries): with an addressable market of at least 600 MSEK.
    • The US and Asian markets have great potential.
    meduniverse.com
  • MediTuner - offers a comprehensive solution for self-management, personalized treatment and improved disease monitoring for patients with asthma.

    More About MediTuner

    Target market

    • Asthma is a variable disease that generally is not accurately diagnosed.
    • 0-70% of all asthma patients do not take their medication as recommended, leading to high medical costs, acute care visits and a lower quality of life for the patient.

    Product/Business idea

    • Asthmatuner is a self-management app that collects data on patients’ symptoms and lung function.
    • Asthmatuner improves adherence to treatment, disease management and asthma diagnosis.
    • Personalized treatment recommendations at the patients’ fingertips.

    Product development and expansion

    • 380 million asthmatics worldwide.
    • Revenue generated from subscription fees.
    • Estimated turnover year 5: 9,5 MUSD.
  • Mimerse - create evidence based automatic psychological treatments in collaboration with leading researchers. They are on a mission to solve the world’s mental health problem and have recently launched their first product to Samsung Gear VR.

    More About Mimerse

    Target market

    Product/Business idea

    Product development and expansion

    Mimerse
  • MindApps - is developing apps in the area of Mental Health. Has developed the market leading app The Mindfulness App and is about to convert the app to a subscription model. Up till today the app has more than 1 million downloads. Under development is also; “MindGym” a digital platform accessible from smart phones, tablets and computers that offer courses, programs and modules within the area of mindfulness and health in its wider sense

    More About MindApps

    Target market

    • 450 million people are experiencing a mental or behavioural problem at any given time, making psychiatric illness one of the leading causes of ill health and disability.

    Product/Business idea

    • MindGym is a digital platform to engage people in a regular training and sustainability of mental health. The user can access it from all digital platforms.

    Product development and expansion

    • Develop the complete platform offering courses and programs in addition to the apps. Also develop content and branding of the product. Launch is planned to take place in January 2016.
  • Navigation Dynamix (NeoDynamics) - offers new technology biopsy system for improved diagnosis of cancer patients.

    More About Navigation Dynamix (NeoDynamics) - Founded in 2004

    Target market

    • Improve accuracy of breast biopsies
    • Increase patient comfort during biopsies
    • Decrease health care costs
    • Our solution

    Product/Business idea

    • High-end biopsy device

    Product development and expansion

    • 1.7 million breast biopsies performed in US alone
    • Reimbursed market place
    • High single digit growth (~9%)
    www.neodynamics.se
  • Optolexia - offers a completely new method for dyslexia screening, enabling early, rapid, reliable and objective identification of children in risk of dyslexia. We free up time and resources for schools and society while improving the lives of many children around the world.

    More About Optolexia

    Target market

    • Difficult to identify people with dyslexia early in life
    • Current dyslexia screening methods are time and resource consuming

    Product/Business idea

    • New automated screening method enabling early, rapid, reliable and objective identification of children in risk of dyslexia.
    • 45 sec test with an accuracy of 95%
    • Technology used; eye-tracking, machine learning and cloud solution.

    Product development and expansion

    • Every fifteenth person has dyslexia
    • Schools and municipalities
    • Growing, unmet need, awareness increases
    optolexia.se
  • Pelago Bioscience - is established to accelerate the use and benefits of the patented CETSA® method in Drug Discovery and Development. Our focus is to deliver physiologically relevant high quality Target Engagement data to customers and collaborators enabling them to develop better and more efficacious new drugs faster.

    More About Pelago Bioscience

    Target market

    Product/Business idea

    Product development and expansion

    Pelago Bioscience
  • Pilloxa - develops a smart pillbox with a connected mobile application in order to facilitate medication for active people.

    More About Pilloxa

    Target market

    • Poor adherence to medication is a multifaceted problem that needs to be solved from a holistic perspective
    • This costs €2M and leads to 4 000 deaths each year in Sweden alone

    Product/Business idea

    • Smart pillbox with a connected app that senses when patients take their medication
    • Connected to systems within IoT and digital health

    Product development and expansion

    • 50 million persons in the EU take medication on a daily basis.
    • An increase of chronic disease will drive the market
    pilloxa.com
  • Premune - Has identified a bacterial protein that activates the immune system during the first weeks of life, preventing future development of allergies.

    Go to website
  • Qinematic - suite of software enables a Kinect sensor to record posture, movement and balance in 3D. The end user is given instant animated feedback. A health professional can quickly and easily analyze performance and generate reports, for better decision making and fast reporting. Testing is automated and takes just a few minutes.

    More About Qinematic

    Target market

    • B2B: health professionals in gyms, clinics, corporate health and retail wellness, who need quick and inexpensive quantitative information.

    Product/Business idea

    • Software for 3D body scanning, analysis of movement & animated user feedback using off-the-shelf hardware.
    • Secure cloud storage and the possibility for remote as well as high volume services.

    Product development and expansion

    • In 2016, we offer a suite of software for automated recording of function, instant onscreen feedback, instant reporting, motion analysis and remote services using tablet or PC.
    qinematic.com
  • Q-linea - ground breaking sepsis diagnostics with pathogen identification and antibiotics resistance profiling within hours from sample taken. 

    More About Q-linea - Founded in 2008

    Target market

    • Sepsis kills people in hours
    • Diagnostic methods of today require days

    Product/Business idea

    • Q-linea’s method will give answer in hours

    Product development and expansion

    • European market > 1 billion Euro
    • US market > 1 billion USD
    www.qlinea.com
  • Scandinavian Biopharma - has developed an oral vaccine for protection against diarrhea caused by enterotoxigenic E. coli in both travelers and endemic populations.

    More About Scandinavian Biopharma - Founded in 2009

    Target market

    • Diarrhoea is the world's biggest killers of children under age of five
    • ETEC is the major  cause of diarrhoeal disease leading to approximately 300,000 deaths among children
    • ETEC is also the most common cause of travellers diarrhoea (TD) – the most frequent health problem among travellers visiting (sub) tropical countries

    Product/Business idea

    • Development of an oral vaccine for protection against diarrhoea caused by enterotoxigenic E. coli in both travellers and endemic populations.

    Product development and expansion

    • A new TD vaccine has a potential of 40 million doses
    www.scandinavianbiopharma.se
  • SensAbues - has developed a breath air collection device for drug testing.

    More About SensAbues - Founded in 2010

    Target market

    • Detect drugs with non-invasive test
    • Detect intoxication
    • Detect next geneneration synthetic drugs
    • Win market shares from urine testing

    Product/Business idea

    • Breath air drug testing
    • Collect aerosols from breath air
    • LC-MS analyze for screening and confirmation

    Product development and expansion

    • 200.000 drug tests every day in EU + US
    • 85 % is urine tests
    • Growing market in S.A + Asia
    • Our target: 10.000 test per day end of 2014
    sensabues.com
  • Senzime - develops unique patient-oriented monitoring systems that make it possible to assess patients' biochemical and physiological processes before, during and after surgery. The solutions are designed to ensure maximum patient benefit, reduce complications associated with surgery and anesthesia, and decrease health care costs.

    More About Senzime - Founded in 1999

    Target market

    • Unmet needs in post-operative patient care- few diagnostic tools
    • High morbidity/mortality due to uncontrolled metabolic changes
    • Undiscovered glucose/lactate levels and high pre-analytical errors
    • Several finger pricks and additional stress to organs during and after surgical interventions

    Product/Business idea

    • A complete monitoring biosensor platform with bedside features that can measure glucose/lactate continuously accessing blood/plasma with no interference
    • Sampling fast response in metabolic changes with microdialysis without the need for needle sticks or additional stress to the organ
    • Fully automatic system providing early detection of severe complications, improving patient care and less handling of staff
    • Specific analysis and advanced monitoring of postoperative care with shorter response time

    Product development and expansion

    • The need for on-line glucose/lactate monitoring in the ICU/OR, has been a priority medical issue for some time now, however in practice few developers appear to have been able to present a solution that works in real life. This is where we consider Senzime stands out. Market potential in the multi billion US dollar range.

     

    www.senzime.com
  • Single Technologies - develops a technology concept that enables high-resolution 3D videos of molecules, living cells and tissue. 

    More About Single Technologies

    Target market

    • Large scale 3D imaging with high resolution
    • Cost efficient instrument

    Product/Business idea

    • Single photon detection system
    • 3D optics
    • Friction free scanning stage

    Product development and expansion

    • High Throughput Screening, $13.7 billions
    • DNA sequencing, $3.5 billions
    • Microscopy, $2.5 billions
    www.singletechnologies.com
  • Swecure - is developing therapies targeting the gut microbiome for treating chronic intestinal diseases, bacterial infections and preventing development of allergy

    Go to website
  • SymCel Sverige - offers a novel system for label free cell based assays to monitor cell activity.

    More About SymCel Sverige - Founded in 2004

    Target market

    • Increasing costs for pharmaceutical development
    • Increased attrition rates

    Product/Business idea

    • Label free cell based assays
    • Novel biological insights
    • Faster, better decisions

    Product development and expansion

    • Pharmaceutical R&D, basic research
    • Toxicology/cosmetics/food monitoring
    • In vitro diagnostics
    www.symcel.se
  • Timesulin - develops life changing medical devices to reduce the burden of chronic conditions. 

    More About Timesulin

    Target market

    • Help patients with diabetes avoid dangerous double doses of insulin.
    • Reduce the intrusion of diabetes onto the daily lives of patients.

    Product/Business idea

    • A replacement cap for insulin pens with a built in timer
    • No buttons, no systems to learn, simple

    Product development and expansion

    • All patients with diabetes (T1 & T2) that use insulin pens, approximately 77 million globally
    • Patients that use pens for drugs beyond insulin such as human growth hormone
    timesulin.com
  • Werlabs - works within preventative medicine. By giving patients access to their health data and helping patients interpret and understand this data Werlabs help them make interventions that have a positive effect on their health. 

    More About Werlabs

    Target market

    • Patients want to have access to and take control over their health data
    • Healthcare today is reactive and only diagnoses and treats patients with symptoms. Response from the healthcare system is slow and outdated.

    Product/Business idea

    • Werlabs offer health checks and blood analyses to individuals and companies.
    • Patients order blood sampling through Werlabs. Accredited partner labs perform sampling and the patient can later access the data together with comments from a doctor through our proprietary online journal.

    Product development and expansion

    • Preventable chronic diseases represent 10% of OECD GDP and cost is expected to rise to over 20% in the coming 20 years.
    • Market size measured in patients willing to pay 112 USD for a blood analysis is estimated to 10% of European population > 1 billion USD.
    werlabs.se
  • Xbrane Biopharma - develops pioneering high demand complex generics with world leading expertise and proprietary high-yield protein expression technology.

    More About Xbrane Biopharma

    Target market

    • Xbrane posses unique know-how in effects of formulation and process parameters on products release-patterns. And in combination with special designed equipment for scale up of production we have demonstrated that we are able to imitate the release pattern of the products in our pipeline.
    • Xbrane optimizes the Biosimilar expression by using our innovative titratable technology and leading know-how, which enable us produce the proteins in a controllable system, with higher yields and better quality.

    Product/Business idea

    • Tunable Protein Expression System
    • Unique process know-how

    Product development and expansion

    • Biopharmaceuticals with combined sales of 80 Billion USD will go off patent until 2025
    • Xbrane’s pipeline of complex generics has an aggregate sales of 10,5 billion USD
    www.xbrane.com
  • XSpray - Specializes in optimizing the performance of challenging drug substances with the RightSize technology platform. Focused on improving targeted oral anticancer agents, foremost protein kinase inhibitors.

    More About XSpray - Founded in 2003

    Target market

    • Protein Kinase Inhibitors (PKIs) are poorly soluble and consequently often plagued by variable absorption, low and erratic bioavailability and unpredictable therapeutic outcome.

    Product/Business idea

    XSpray’s RightSize technology is able to formulate these compounds with:

    • Significantly better oral bioavailability over a broad pH range
    • Less pH-dependent absorption & biobailability
    • Potential to enable a lower oral dises

    Product development and expansion

    • Global PKI market was nearly B$29 in 2011
    • There are 935 open clinical studies for PKIs
    • The majority of PKIs are poorly soluble, proving difficult, slow and expensive to formulate successful pharmaceuticals today.
    Xspray.com